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The signal cannot however jump the synapse without assistance.

The message can only travel when the neuron releases a neurotransmitter to fill this gap and allow the signal to transient via it.

In addition to Sceletium's common use for the stress and mental fatigue of modern industrial living, Sceletium has been used as a natural supplement in: Sceletium elevates mood and decreases anxiety, stress and tension.

Kanna has also been used as an appetite suppressant by shepherds walking long distances in arid areas.

People taking any psychiatric drug (including all anti-anxiety drugs, sedatives, hypnotics, antidepressants and anti-psychotics and so-called designer or recreational drugs) or any cardiac medications, are advised not to take Sceletium-containing products.

As with most supplements and modern drugs, safety in pregnancy for Kanna has not been established.

Historically effect in the mouth, much like kava, and is used by the San tribes if you are about to have a tooth extracted, or in minute doses, for children with colic.Mesembrine is an alkaloid which is derived from the Sceletium Tortuosum plant and is now being acknowledged as a key active component in the ability of the plant to produce beneficial effects which are closely related to it are the alkaloids mesembrenone, mesembrenol and tortuosamine, which are also present and produce very similar effects to mesembrine.Fermenting Kanna increases mesembrenone and decreases mesembrine.To permit recovery of the neuron to receive new messages, the brain takes away the neurotransmitter from the neuron receptors and permitting it to be sent back to the originating nerves, a process known as re-uptake.In individuals suffering from depression, the neurotransmitter serotonin (also known as 5-hydroxytryptamine) is lacking.

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